Gentamicin is used to treat severe or serious bacterial infections.
Gentamicin may also be used for purposes other than those listed in this medication guide.
Pharmacology: Inhibits production of bacterial protein, causing bacterial cell death.
Indication: Short-term treatment of serious infections caused by susceptible strains of microorganisms, especially gram-negative bacteria; adjunct to systemic Gentamicin in serious CNS infections (injection); treatment of superficial ocular infections (ophthalmic); treatment of primary (eg, impetigo contagiosa) and secondary (eg, infectious eczemafoid dermatitis) skin infections; skin cysts and superficial skin infections, infection prophylaxis, and aid to healing (topical).
Gentamicin is a broad spectrum aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.
Gentamicin belongs to a group of antibiotics called Aminoglycosides. They work by binding with the 30S bacterial ribosome thus interrupting protein synthesis. When taken orally the drug is not effective due to inactivation in the liver. Therefore it must be administered intavenously, intramuscularly or cutaneously.