Pregnancy:D Lactation:L4 Lab:NA Food:NA
Acute leukemia, HIV related kaposis sarcoma.
Alopoecia and dermatological reactions. Extravasation of daunorubicin may cause severe local tissue necrosis damaging surrounding muscles, tendons and nerves. IV infusion, back pain, flushing and chest tightness. Bone marrow suppression, cardiac toxicity, cardiomyopathy and congestive heart failure.
Increased risk of hepatic toxicity when used with hepatotoxic drugs e.g. high-dose methotrexate. Increased risk of cardiotoxicity when used with cyclophosphamide. Immunisation with live vaccines is not recommended. Concurrent radiation may lead to increased radiation reaction.
MECHANISM OF ACTION
Daunorubicin forms a stable complex with DNA and interferes with the nucleic acid synthesis. It is a cell-cycle nonspecific agent, but its cytotoxic effects are mostly marked in the S-phase. It also has immunosuppressant and antibacterial effects.